Exigliptin M-500 Tablets

Composition

• Teneligliptin Hydrobromide Hydrate – 20 mg
• Metformin Hydrochloride (Extended Release) – 500 mg

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Mechanism of Action

Teneligliptin is a potent DPP-4 inhibitor that increases incretin hormone levels (GLP-1 and GIP). This enhances glucose-dependent insulin secretion and suppresses glucagon release, improving postprandial glucose control.

Metformin Hydrochloride (Extended Release) reduces hepatic glucose production, improves insulin sensitivity, and enhances peripheral glucose uptake. The extended-release formulation allows gradual drug release, providing sustained glycemic control with improved gastrointestinal tolerability.

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Key Benefits

• Dual-action control of blood glucose levels
• Effective in reducing fasting and postprandial glucose
• Helps lower HbA1c levels
• Low risk of hypoglycemia
• Improved gastrointestinal tolerability due to extended-release formulation
• Convenient once-daily dosing

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Indications

• Type 2 Diabetes Mellitus
• Patients inadequately controlled on monotherapy
• Combination therapy for improved glycemic control

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Dosage & Administration

• To be taken as directed by the physician
• Usually administered once daily with meals
• Tablets should not be crushed or chewed

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Precautions

• Use with caution in patients with renal impairment
• Regular monitoring of blood glucose is recommended
• Not indicated for Type 1 Diabetes or diabetic ketoacidosis
• Avoid excessive alcohol consumption

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Contraindications

• Severe renal impairment
• Known hypersensitivity to any component
• Metabolic acidosis

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Storage

• Store in a cool and dry place below 25°C
• Protect from light and moisture
• Keep out of reach of children

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Packaging

• 10 x 10 Tablets